NAD+ Precursors Compared: NMN vs NR vs Niacin vs NAM — The Complete 2026 Guide If you’ve spent any time in the longevity world, you’ve heard that NAD+ is critical for aging. Older organisms have lower NAD+. NAD+-restoring interventions extend lifespan in animals. Therefore, you should take NAD+ precursors to stay young. The logic feels […]
Semaglutide vs Tirzepatide for Longevity: Beyond Weight Loss, What Does the Data Show? (2026) GLP-1 agonists have taken over the health conversation, but most people are asking the wrong question. They’re obsessing over weight loss when the real story is what these drugs do to your metabolism, inflammation, and cardiovascular risk. I’ve reviewed every major
Senolytics Compared: Fisetin, Dasatinib + Quercetin, and Navitoclax — What the Evidence Shows (2026) Most longevity interventions feel like shots in the dark: hope the mechanism holds up, hope it translates to humans, hope you survive the side effects. Senolytics are different. They target something real—senescent cells—and we’ve known what they do to aging for
Urolithin A vs CoQ10: Which Mitochondrial Supplement Is Worth Taking? (2026) Mitochondria are the aging cell’s achilles heel. As you age, your mitochondria become dysfunctional—slower at producing ATP, generating more oxidative stress, and failing to trigger the quality control mechanisms that normally clear damaged mitochondria. Both urolithin A and CoQ10 claim to fix this, but
Fisetin vs Quercetin: Which Senolytic Flavonoid Is More Effective? (2026) Senolytics—drugs or compounds that selectively kill senescent cells—have become the hottest thing in longevity science since NAD+ precursors. And the two compounds most people ask me about are fisetin and quercetin. Both are natural flavonoids. Both kill senescent cells in lab conditions. Both are cheap.
Rapamycin vs Metformin for Longevity: What the Evidence Actually Shows (2026) If you’ve read anything about longevity science in the past five years, you’ve seen rapamycin and metformin compared endlessly. I’ve literally made investments in companies developing both compounds for aging. But here’s what bothers me: most comparisons are oversimplified. People say “rapamycin is stronger”
BPC-157 vs TB-500: Which Peptide Is Better for Recovery and Healing? (2026) I’ve been tracking peptide research since 2015, when these compounds were barely on the radar outside of elite sports science circles. Today, BPC-157 and TB-500 are two of the most sought-after compounds in the longevity and recovery space, with thousands of people ordering
NMN vs NR: Which NAD+ Precursor Is Actually Better? (2026 Evidence Review) If you’ve been down the longevity rabbit hole for more than five minutes, you’ve heard about NAD+—that critical coenzyme that powers mitochondrial function, DNA repair, and cellular energy production. But here’s the thing: you can’t just take NAD+ directly. Your body needs precursors.
The Shift From Autocomplete to Agents: What Changed Two years ago, the state-of-the-art AI coding tool was GitHub Copilot—basically autocomplete on steroids. You’d start typing a function, and it would suggest the rest. It was useful for the obvious cases—writing a for loop, implementing a standard algorithm—but it required you to direct every step. You
The State of Open Source LLMs in 2026: Quick Landscape The open-source LLM ecosystem has gone from fragmented to stratified. You have a few clear tiers now. At the top tier, you have models that compete with the best closed-source options. Llama 4 from Meta, Mistral models, and DeepSeek’s latest release are all in this