Fisetin vs Quercetin: Which Senolytic Flavonoid Is More Effective? (2026)

Senolytics—drugs or compounds that selectively kill senescent cells—have become the hottest thing in longevity science since NAD+ precursors. And the two compounds most people ask me about are fisetin and quercetin. Both are natural flavonoids. Both kill senescent cells in lab conditions. Both are cheap. And both have hype cycles that completely outpace the evidence.

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